Haematological changes: Eosinophilia, haematoma or bleeding, thrombocytopenia, neutropenia, leukopenia, granulocytopenia and haemolytic anaemia. Isolated cases of agranulocytosis (<500/mm) have been reported, most of them following total doses of 20 g or more.
Exanthema, allergic dermatitis, pruritus, urticaria, oedema, erythema multiforme may occur.
Other adverse effects include headaches and dizziness, increase in liver enzymes, oliguria, and increase in serum creatinine, mycosis of the genital tract fever, shivering and anaphylactic or anaphylactoid reactions.
Local: Inflammatory reactions in the vein wall may occur after IV administration. These may be minimized by slow (2-4 minutes) injection. Intramuscular injection without lidocaine solution is painful.
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